Bone Strengthening Drugs Linked to Lower Breast Cancer Incidence | Bone Strengthening Drugs

Bone Strengthening Drugs Linked to Lower Breast Cancer Incidence | Bone Strengthening Drugs

Submitted by: Medico News

New research from the US has discovered that women who used bisphosphonates, commonly-prescribed bone-strengthening drugs, had significantly fewer invasive breast cancers than women who did not use them. “The idea that bisphosphonates could reduce breast cancer incidence is very exciting because there are about 30 million prescriptions for these agents written annually in the US targeting bone health, and more could easily be used to counteract both osteoporosis and breast cancer,” Chlebowski told the media. For the study, Chlebowski and colleagues re-analyzed data from the Women’s Health Initiative (WHI), a large observational study set up by the National Institutes of Health (NIH) in 1991 to examine the most common causes of death, disability and impaired quality of life in postmenopausal women. The WHI collected information on cardiovascular disease, cancer, and osteoporosis.

In the 150,000-plus cohort of generally healthy postmenopausal women, the researchers found 32 per cent fewer cases of invasive breast cancer among women who used bisphosphonates (mostly alendronate, marketed as Fosamax by Merck), compared to women who did not use such drugs.

What prompted the study were the findings of a report from a breast cancer trial that suggested bisphosphonate zoledronic acid given intravenously every 6 months resulted in fewer cancers in the other breast.

Chlebowski said that:

“It appeared to make bone less hospitable to breast cancer.”

In deciding how to devise the study, the researchers had to find a way to control for bone density, since that in itself is a risk factor for breast cancer. In other words they had to devise a way to control for potential differences between the women prescribed bisphosphonate and those not prescribed bisphosphonate, because those on the bone-strengthening drugs were on it because they had low bone mineral density, which is linked to lower breast cancer incidence.

They found that about 10,000 of the cohort had their bone mineral density analyzed as part of the WHI study, and for the others, including those prescribed bisphosphonates, the researchers used a 10-item hip fracture predictive score to measure bone density.

Thus they were able to correlate the results of bone mineral density tests in the 10,000 who had the tests with the predictive score in order to correct for any potential difference in bone density in women using bisphosphonates compared to those who did not use them.

Thus prepared, Chlebowski and colleagues then studied data on 2,216 women who were using bisphosphonates when they entered the WHI study.

The results showed that:

Only 64 of the bisphosphonate users developed breast cancer, and most of the cases, (50 of them), were estrogen-receptor positive.

Overall there was an average of 32 per cent fewer breast cancers among bisphosphonate users compared to non-users.

There were 30 per cent fewer estrogen-receptor positive cancers and 34 per cent fewer entry-receptor negative cancers among bisphosphonate users, although the latter finding was not statistically significant due to low numbers.

Speculating on what effect bisphosphonates might have to cause fewer breast cancers, Chlebowski said it could be because the drugs discourage blood vessel formation (which tumors rely on to grow), and help the immune system:

“Bisphosphonates reduce angiogenesis and stimulate immune cells responsible for tumor cell surveillance as potential mediators,” explained Chlebowski.

He said we need to study this link in more detail, because “while we currently have several options for reducing receptor positive breast cancers, none are available for receptor negative cancers”.

Other studies presented at the symposium pointed to a similar link between bisphosphonate use and lower breast cancer risk, and a number of breast cancer trials evaluating oral and intravenous uses of the drug are about to report randomized clinical trial evidence on it.

About the Author: Written by Medical News | Cancer News : http://mediconews.com Dental News : http://mediconews.com

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A Helpful Tool For People Searching For Clinical Research Trials



Sometimes the search for a good doctor can be quite nerve wracking even under the best of circumstances, but the emotional burden becomes even greater when searching for doctors who are participating in clinical trials.

Trial Reach and CureClick know this; so they developed a tool which makes the search for clinical research trials a bit easier.

Last July CureClick and Trial Reach asked if I would like to help out with this task; since I'm a CureClick Ambassador I was happy to help.

At this very moment you can use the Trial Reach Clinical Trials Search Tool that I embedded in the sidebar of Living Fit, Healthy and Happy(SM).

The clinical trials search tool is absolutely amazing! The tool is designed so that users can search for any clinical trial for any condition. Then the tool provides relevant results based on the user answering a few questions. Now you can search for clinical trials that best fit your needs.

Although I receive a small one time payment for installing the Trial Reach Clinical Trials Search Tool on Living Fit, Healthy and Happy(SM), the potential benefit to all of you is what inspired me to install it on this website. So, please take the time to use it. And tell all of your family and friends about it, too!

To learn more about my relationship with CureClick and why I'm talking about clinical trials, please click on this link.



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Bite Into a Healthy Lifestyle

Bite Into a Healthy Lifestyle

Submitted by: Michelle Stewart

It is great to see that Spring is definitely on the way. Now is the time to seriously focus on the Spring cleaning of the refrigerator and pantry. I agree with you--it can be a grungy job but it’s one that has to be done. It is a great chance to clear out the clutter of fossil foodstuffs beyond their date of optimum quality and nutrients. We’ve all looked into the ‘fridge and found a container that we were convinced was a science experiment! Some things probably need to go for good, some you’ll need to replenish ensuring that you have plenty of the right stuff on hand to aim for a healthier lifestyle. Here are some of my picks to stock for good health.

High Nutrient Food Choices

Beans and legumes are under the banner of high nutrient selections. Beans are good sources of protein, high in fiber and antioxidants. Peanuts, which are really legumes and not nuts are also high in protein and contain mono and polyunsaturated fats which promote heart health.

Whole grain foods are wise choices; they are high fiber which is one of the nutrients most people can use more of. Fiber will help give you a feeling of satiety or fullness; it aids in digestion and helps you maintain a healthy colon.

Low fat dairy such as milk, cheese and yogurt are a good source of vitamin D, calcium and protein. These nutrients help maintain bone density and are linked to lower blood pressure. Research also indicates that calcium from low fat dairy products may have a role in body-weight regulation. It is important to read food labels; sometimes low fat products have higher amounts of sodium which is something you want to avoid.

Better for You Snacks

Snacks are important and an excellent aid to staying on track. They are good sources of energy and provide vitamins and minerals that you need. However, this does not mean eat as much or as many of the snack as you can---choose healthy snacks, eating a moderate or the recommended amount. For example:

-Whole grain moderate to low-sodium crackers

-Whole grain granola bars

-Low fat Greek-style yogurt

-Canned fruit in natural juice

-Fresh Fruit i.e. apples, strawberries, pineapple, and blueberries

-Vegetable sticks, i.e. carrots and celery

-Rice cakes with peanut butte

-Nuts, about 1-ounce.

-Trail-mix, about 1-ounce


-Sunflower seeds

Liquids to Love

It is essential that you drink plenty of liquids for good health. Humans can survive about a month without food, take away those fluids and survival is limited to a few days. Stay hydrated, drink plenty of water; I recommend eight to ten glasses a day. If you’re looking for fluid options in addition to water, you can find an array of healthy beverages. From nutrient-enhanced water, to sport beverages, to juice drinks enhanced with antioxidants and vitamins, thirst-quenching has never been so easy. Most importantly remember that all beverages hydrate. If you get thirsty, that is a signal of dehydration and dehydration is sometimes confused with hunger.

I’m not saying you can’t enjoy food, just plan to bite into healthy food options on a daily basis. Renew your focus, and clear your mind to think of the positive rewards of health and well-being.

Take Away: High nutrient foods, good-for-you snacks and healthy beverages are best bets to keep your plans moving forward for a healthier you.

About the Author: Michelle J. Stewart MPH, RDLD/N, CDE is an experienced food and nutrition communication expert specializing in wellness with a holistic approach to living your best life. Michelle has been leading the way to a healthier you for more than 25 years. She is zealous when it comes to wellness from the inside out and empowering whomever she comes in contact with to take charge of their health and wellbeing. Her motto is "EAT LESS MOVE MORE" Sign up for her Free Report 10 Weight Loss Tips for Life when you visit http://thenutritionplanner.com

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Free Weights Equipment Can Add To Overall Health

Free Weights Equipment Can Add To Overall Health

Submitted by: Kevin Urban

Face it, not everyone wants to look like a Sherman tank. Many think the overall outcome of a good free weights equipment training program will be a bulky, hulk-type look. This simply isn’t so. Weight training can add so many benefits to an overall health program that it’s crazy for people not to take advantage of this simple and relatively inexpensive form of exercise.

Effective weight training programs are just one portion of an overall fitness plan. Lifting, cardiovascular exercise, diet and even stress reduction all come into play if total health improvement is the goal. Lifting free weights, however, is a key component that shouldn’t be overlooked when equipping a home gym.

By toning, strengthening and even bulking up muscles – if that’s the program’s desired outcome – a person can help improve their appearance, muscle endurance, strength and even outlook on life. Muscles that are toned, firm and fit also help a person training with free weights prevent injury and even prevents osteoporosis at a later age, which is now considered a concern for men and women alike.

Getting started using free weights can be a little tricky, but it’s not rocket science. A training program involves making sure whatever weights and exercises you incorporate are handled with care. Since weight lifting equipment enables a huge range of motion, it’s important to learn proper form and follow it. Injury can result with over lifting and hyperextensions, so being informed before starting to train is just a good idea.

Once a good plan is put into place, free weights can be a really fun endeavor to add to a fitness program. The challenges of lifting and doing it right are fun and rewarding. The rewards are visible and often quite easy to track. Results can be seen by following a program that only involves a few days a week. It’s not necessary to train on the equipment seven out of seven to improve conditioning.

Weight training equipment can provide huge benefits physically and psychologically. Just remember when getting started to arm yourself with good information and then enjoy from there!

About the Author: Kevin Urban is the editor at http://www.best-home-gyms.com, a consumer guide on home exercise equipment.

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Benefits Of Strength Training

Benefits Of Strength Training

Submitted by: Ken Bendor

The benefits of a good strength training program are almost endless. Less disease, happiness and most importantly, showing off your muscles at the beach.

Strength training should be part of everyone's routine. Even if you are low on time, strength training, according to the ACSM (American College of Sports Medicine), only needs to be done 2-3 times per week with each session lasting no more than one hour. For 2-3 hours per week, huge benefits can be realized.

Regular strength training will:

**help you in day to day activities around the house and in your yard. It will keep you independent which is especially important in the older population. Imagine not being able to lift a 5 pound bag of flour or take the garbage out by yourself.

**lower the risk of osteoporosis, hypertension and diabetes.

**help you avoid lower back pain.

**increase bone density which is important for post menopausal women.

**increase muscle mass which burns more calories throughout the day than an equal amount of fat.

Even with all these benefits, many people are reluctant to start training with weights. Concerns include injury, incorrect form and for women; not wanting to grow muscles and look like a man.

When beginning your strength training program, the risk of getting hurt can be greatly reduced by starting out with machines rather than free weights. As you become more comfortable with the machines, slowly learn to use free weights. If you want to stick with the machines, know that they will give you the same benifits as free weights. As for the concern that women will look like men, it won't happen without the help of steroids, which you shouldn't even consider using.

Sometimes when we think of being healthy, we think of eating and running. While these are important, strength training should never be left out. Strength training provides benefits to your health that cannot be found with any other mode of exercise and shouldn't be forgotten.

About the Author: Ken Bendor is a Senior at Florida State University studying Exercise Science and Dietetics. He started http://StraightHealth.com to try and spread easy to understand and accurate information on health and fitness. http://straighthealth.com

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What Vital Nutrients Is Your Diet Missing?

What Vital Nutrients Is Your Diet Missing?

What Vital Nutrients Is Your Diet Missing?

By: Lee Dobbins

People today do not eat as well as they did even 30 years ago and many of us are starved for essential nutrients and don't even realize it. With today's fast paced lifestyles, it's more convenient to grab a fast food meal or energy bar then to cook up a balanced meal full of the nutrients our bodies need to work their best.

Our diets are woefully lacking in fruits and vegetables which provide us with vitamins, minerals, enzymes and fiber that help your immune systems fight off illness and disease. And when we do eat fruits and vegetables chances are they are full of pesticides and chemicals. No wonder our health on the whole is declining!

Below are several essential nutrients that are probably missing from your diet. Going for the quick fix and replacing them with supplements won't make up for the synergistic effects of these nutrients found in food and if you want to avoid the harmful effects of pesticides then it's best to go with organic foods when possible.

Vitamin A
Vitamin A gives us healthy eyes as well as helps to maintain the linings of the intestinal, respiratory, and urinary tracts. It also helps keep our skin healthy. To get more vitamin A in your diet, eat darkly-pigmented foods such as spinach, carrots, winter squash, kale, and sweet potato.

Vitamin C
Vitamin C is needed in order for our body to create collagen, which is basically the glue that holds our skin, bones and blood vessels together. It also aids in making brain chemicals, neutralizing damage from free radicals, and metabolizing cholesterol. Vitamin C has also been shown to help reduce arthritis, diabetes and heart disease. To add this vitamin to your diet, drink add a glass of orange juice or eat an orange every day. Other foods that contain vitamin C are strawberries, kiwifruit, red bell peppers, cantaloupe, Brussels sprouts, and broccoli.

Vitamin E
Vitamin E is an antioxidant that helps to neutralize free radicals and protect cells from damage. It plays a key role in the immune system and can even help prevent the common cold as well as lower the risk of Parkinson's disease. Foods high in vitamin E include sunflower kernels, almonds, and sunflower oil especially when used in salad dressings, which helps you get nutrients from the vegetables as well as carry the vitamin E into the bloodstream.

Fiber is the part of fruits, vegetables and whole grains that is not digested. Whole grains can lower your heart disease risk by 30 percent. It is recommended that you get 14g of fiber for every 1000 calories you eat. To get more fiber in your diet have a 1/2 cup serving of Fiber One cereal and add more beans to your diet. Switch to whole grain bread and eat lots of fruits and vegetables with your meals.

Calcium helps us build and maintain healthy teeth and bones. It prevents bone-thinning osteoporosis and also contributes to healthy blood pressure. Recent studies have shown that calcium can reduce the risk of colon cancer. To get enough calcium, drink three glasses of low-fat or fat-free milk a day, or eat eight ounces of fat-free yogurt along with 2-3 ounces of low-fat cheese evert day.

Magnesium and Potassium
Magnesium works together with calcium and along with potassium it is linked to healthy blood pressure. These two nutrients are also though to help protect against osteoporosis, diabetes, heart disease, and stroke. To get more magnesium, add a half-cup of bran and cooked spinach each day. For more potassium, eat sweet potatoes, white potatoes, bananas, and white beans.


Author Bio
Lee Dobbins writes for the A2Z Vitamin And Herbs Guide For Natural Healing where you can find out more about vitamins and herbs as well as natural healing methods.

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Strengthen Yourself with Strength Training Exercises


Praveen Pandey

What do you feel when you see an old man walking with the support of a stick? What thoughts run through your mind when you see a lady moving in a wheel chair, due to weak bones? Would you like to live a similar life when you get old? No, as no one desires a handicapped life. Everyone wants to stay active and mobile till their last breath. Exercising regularly will help you do that. And strength training is an optimal way to keep you moving as it helps in building lean muscle mass. Well toned muscles can help in all your daily activities, whether it's carrying groceries, climbing stairs or doing the laundry.


Strength training involves adding resistance to the muscle groups as you workout. Through strength training you will not only gain lean muscle mass, but you will, as a result of building muscle, burn fat more effectively. Anyone, old or young, male or female who wants more strength and endurance, can benefit. Strength training can help prevent osteoporosis and build muscle even in elderly people. This is important since, as people get older, they tend to lose muscle mass and tone. Even people in their 80's and 90's can greatly increase strength through weight training. Another benefit of weight training is that well toned and larger muscles burn more calories even when you are doing absolutely nothing. So a regular weight lifting program can help you lose fat and control blood glucose levels in the long run, both during and in between workouts. It may also help reduce the risk of heart disease.


There are several approaches to weight training. It can be as simple as lifting a small set of hand weights in your living room. Or you may want to join a gym or health club where you will have access to a whole array of weight machines and exercise equipment. Most weight training programs involve sets of weight lifting exercises. Each set consists of a series of repetitions. When you first practice, start with one set each session. Gradually work your way up to three to six sets each session. Take a rest for a few minutes between each set of repetitions. As you become stronger you will find that you can lift more weight.


Discuss with your doctor before starting any weight lifting routine, as in some people, lifting weights can increase the risk of worsening diabetes or cardiovascular complication if not done the right way. Always do some sort of aerobic exercises such as walking, jogging or jumping rope for 5-10 minutes to warm up before lifting weights. Do not forget to cool down after strength training session. Always allow at least a day's rest between workout sessions or alternate upper body training one day, with lower body training the next.


Exercising with a trainer would be beneficial as he/she can help you if something goes wrong. Strength training is an essential element of fitness for virtually every sportsman and sportswoman. So start with strengthening exercises to get sportive in your life!

Get tips, recipes and products related to exercise and fitness, at Healthizen.com.

Get Out For Vitamin D or Suffer

Get Out For Vitamin D or Suffer

Submitted by: Kya Grace

If you look closely at your dinner plate or for that matter any food that you eat during the day, hardly anything in it contains Vitamin D. And the best source of this vitamin is free and abundant in nature. Sunlight is the best source of Vitamin D and adequate exposure to sunlight is sufficient to provide the body with its optimum requirement of the Vitamin.

Vitamin deficiency results in some serious and chronic health problems. Weak bones, Alzheimer, Parkinson’s, influenza and some forms of cancer are associated with Vitamin D deficiency. Some foods such as cereals are available fortified with Vitamin D to address this problem for those who are suffering from lack of it, but this alone may not be enough or regulated to make up for the deficiency. An all cause mortality rate has been observed by a comprehensive study focusing on Vitamin D deficiency and large scale studies also link the deficiency to be one of the major causes of terminal diseases like peripheral artery disease, high blood pressure leading to cardiovascular arrest. Babies born with Vitamin D deficiency are at high risk of developing schizophrenia.

The skin containing epidermis which is layered from outer to inner surface of the skin is responsible for producing Vitamin D by reacting with the ultraviolet spectrum of sunlight. People in all regions of the world can get sufficient supply of Vitamin D from sunlight which is available throughout the year in Tropics and during summers in cold temperate regions except the arctic’s, where sunlight is very low and insufficient.

In earlier times before the advent of computer age, dense industrialization and urban living, the great outdoors was the playground of mankind. Work and play, celebrations and events were mostly held during the day under the sun and the population got its supply of the vitamin without raising a finger. In fact being out in the sun for far too long exposed them to the risk of skin cancer, but that was a small risk compared to what we have done to ourselves by confining to enclosed spaces, darkened interiors and invited a menu of diseases that will put a horror story to shame.

The present sedentary lifestyle which we call modern living is paved with health hazards. Life has become a spectator sport and most people are content watching others live and play on their television screens and not budge an inch out of their couches. An average city dweller spends roughly thirty to thirty five hours a week ogling the idiot box like a couch potato, unexposed to nature’s elements, living in a controlled artificial environment.

Kids stay indoors playing on their game consoles for hours on end, or spend hours on computer terminals surfing and chatting the day away. At an age when they should go out more often to play and explore the natural world, they are confined to stifling stuffy homes where they watch the sun out of their windows and miss the beauty of a rising sun in the morning.

Working class leave homes to again park themselves in enclosed spaces of the offices and workplaces and by the time they leave, the sun is already gone. Elderly people because of their physical condition are mostly confined to old age homes, whiling the time away in the depressing indoors, rarely going out to catch sunlight. People from all age groups are prone to Vitamin D deficiency and their lifestyle is responsible for all the diseases that follow from it.

About the Author: If you would like to attend a free session with a Personal Trainer in Bondi or to hire Sydney Personal Trainers, visit Sydney Personal Training.

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Importance of weight training


Praveen Pandey

Weight training is an exercise technique which uses external weights, the body's resistance, or other devices to exercise and strengthen a body muscle. Most people, especially men, opt for such training to get an attractive physique with big muscles. However, its benefits go way beyond. Weight training, also known 'strength' or 'resistance' training, enables you to do everyday tasks like lifting, carrying, and walking up stairs with greater ease.

Strength training helps protect against diseases like arthritis, osteoporosis, sarcopenia (loss of body mass), lower-back pain, and other disabilities. It protects the joints, enhances joint stability, improves bone density, and reduces bone deterioration. More muscle power puts less strain on the joints and connective tissue when lifting or exerting. Strong muscles, tendons, and ligaments are less prone to injury.

Working against the body's resistance or exercising with light weights also assists in managing chronic illnesses such as heart disease, stroke, high blood pressure, diabetes, and hyperlipidemia. When you are active, the heart muscles can perform better even with less oxygen. Lifting weights can normalize the blood pressure and decrease the levels of blood sugar and cholesterol. A combination of regular weight training, a protein-rich diet, and some cardiovascular exercises can help to achieve a healthy weight and a fitter body.

Such a combination not only tones up the muscles and shapes the body along with weight loss but also improves anaerobic endurance. It improves the composition of the body and increases the lean body mass. Weight training mainly stimulates the development of muscle tissues and also strengthens them. Muscle tissue, being more active than fat tissue, helps to burn more calories. Increase in muscle mass normalizes and even increases the basal metabolic rate, as a result of which one can burn more calories at rest.

By working out the muscles through their full range of movements, weight training increases flexibility and reduces the risk of suffering from a muscle pull. Weight training has enormous advantages. If a person follows a proper diet, has precise control over his movements, and maintains correct posture, he or she stands to gain the most from such an exercise program. It is advisable for all adults to weight train their major muscle groups at least twice weekly.

Are you a fitness freak? Read articles on Diet Plan, Fitness, Weight Loss, and Health Care at Healthizen.com.

Exercise Your Way Through Perimenopause

Exercise Your Way Through Perimenopause

Submitted by: Susan Megge

It’s unfortunate, but most women don’t realize how crucial a role regular fitness and exercise is to reducing many symptoms associated with perimenopause. As women approach menopause they begin to gain weight, especially around their mid-section. This abdominal weight is quite common and the result of declining hormone levels, which may cause the metabolism to slow down significantly.

Most women will notice a significant amount of fat deposition around the area of their mid-section or abdomen. You’ll especially want to avoid or eliminate this added weight due to the fact that this type of fat plays a significant role in contributing to heart disease, the number one killer of middle-aged and older women. You may not think that losing your added weight is possible, but it is; this weight gain can be eliminated quite easily by simply getting into a regular exercise routine. Fitness and regular activity are the keys to decreasing weight and avoiding many conditions associated with aging. If you’re willing to commit to a regular exercise routine - one that includes weight bearing exercises - you will change the muscle-to-fat ratio, enabling you to increase your metabolic rate and burn calories, even at rest.

In addition to weight gain, if you’re in your thirties or beyond, you’re also beginning to lose bone mass at a rate of approximately 1% per year. This rate will increase to 2%-3% per year after menopause. Many studies have proven that exercise can increase a woman's bone density, which reduces the risk of osteoporosis and the incidence of falls and bone fractures associated with osteoporosis. As you may know, osteoporosis goes undetected in many women until bone fractures occur; if, however, you take preventative measures, such as getting into a regular fitness routine, you can indeed reduce this risk.

Exercising regularly can also be beneficial in reducing the occurrence of hot flashes, a common symptom women experience as they approach menopause. Hot flashes have been known to contribute to impaired sleep patterns and a decreased energy level. If you’re not getting enough sleep and are feeling sluggish, it’s quite likely that this may affect your overall mood, which has the potential to negatively impact both personal and professional relationships. Estrogen replacement therapy has been shown to decrease these symptoms, but many women prefer to seek natural alternatives; obviously, exercise has proven to be a very viable alternative for a great number of women.

In summary, making fitness and exercise a priority will benefit most women who are experiencing symptoms of perimenopause, and the positive results - both physical and emotional - are well worth the extra time you’ll spend once you begin and continue a regular exercise routine. I know it’s easier to make excuses to not exercise, but you love your family and yourself; therefore, take just a little extra time to ensure that you feel good, look good and have loads of energy to participate in all of life’s offerings.

About the Author: Susan Megge is the founder of http://www.40isbeautiful.com, a website designed to assist mature women as they approach and experience menopause. Susan, a health and fitness expert, started experiencing symptoms of menopause several years ago and researched various avenues to deal with these symptoms naturally.

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