by

Joseph

A recent lab study may hold remarkable promise for the treatment and prevention of breast cancer.

According to the results of a study published in the International Journal of Cancer, researchers have demonstrated that a hormone released after exercise reduced migration and multiplication of malignant cancer cells.

If these results could be demonstrated in animal and human studies, medical science may have another weapon in the arsenal to treat and prevent breast cancer.

Kristina A Trujillo from the Department of Biochemistry and Molecular Biology at the University of New Mexico, and her colleagues from the University of New Mexico and Chapman University knew that exercise is beneficial for improving cancer prognosis  lowering disease risk, and that irisin provides benefits for metabolic diseases including cancer.

So the research scientists tested effects of various concentrations of the hormone on malignant and non-malignant breast cancer cells.

They found that irisin effectively reduced the migration, number and viability in malignant breast cancer cells while not harming non-malignant breast cancer cells.

Now this is an important finding, as I'm about to tell you.

Breast cancer is a very serious disease. In fact, the US Centers for Disease Control and Prevention (CDC) says that in 2011

• 22o,097 women and 2,078 men were diagnosed with the disease in the U.S.
• 40,931 women and 443 men in the US died from the disease

Breast cancer strikes any age or ethnicity. It is the second most common form of cancer among Asian/Pacific Islander, black, Alaskan/Native American, white and Hispanic women.

Cancer is dangerous and often deadly because it's mitosis run amok. Humans and animals replenish themselves through mitosis, a mechanism whereby cells multiply to make new versions of themselves.

It's a sophisticated and remarkable mechanism and often works very well. But God did allow for the human body and animal body to make mistakes thus sometimes cells go on multiplying even beyond the body's ability to sustain them.

The malignant cells can even spread to other parts of the body causing problems for other organ systems. If left to itself this will continue until the person or animal dies.

But irisin stops the malignant cells from multiplying, spreading to other cells and even more remarkable, fouls up the cancerous cells so that they will die.

Trujillo and her colleagues also noted that irisin enhanced effectiveness of doxorubicin (Dox) a cancer fighting medicine when added to vast spectrum of irisin concentrations in malignant cell types.

The research team also noted that irisin suppresses activation of NFκB; NFκB is a protein that regulates genes involved in inflammation and immune response. Thus NFκB helps cancerous cells to survive and proliferate.

Therefore it is very significant that irisin suppresses this ability.

I see this as further proof that God lives. He created mechanisms which can save as well as kill the body. It's up to us to figure out how these mechanisms work.

Exercise Can Save Lives

Other studies have shown that exercise can prevent breast cancer.

In a study involving 2609 female participants, scientists from Gillings School of Global Public Health at the University of North Carolina at Chapel Hill found that women who participated in moderate levels of exercise e.g. walking were able to reduce their chances of developing breast cancer by 30%.

Moreover, results of American Cancer Society Cancer Prevention Study II Nutrition Cohort study of 73,631 postmenopausal women found that post menopausal women who walked for even 1 hour per day lowered their breast cancer risk by 14% compared to women who didn't exercise.

While those studies involved humans, Trujillo et al tests on malignant and nonmalignant cells holds promise for the development of treatment methods in the future.

"Our observations suggest that irisin may offer therapeutic benefits for breast cancer prevention and treatment possibly through an anti-inflammatory response, induction of apoptotic cell death, or through enhanced tumor sensitivity to common antineoplastic agents such as Dox." Trujillo and her colleagues concluded.

1 But God remembered Noah and all the wild animals and the livestock that were with him in the ark, and he sent a wind over the earth, and the waters receded. Genesis 8:1

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Article Reference

Gannon NP, Vaughan RA, Garcia-Smith R, Bisoffi M, & Trujillo KA (2015). Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behavior in vitro. International journal of cancer. Journal international du cancer, 136 (4) PMID: 25124080

Chang TP, & Vancurova I (2013). NFκB function and regulation in cutaneous T-cell lymphoma. American journal of cancer research, 3 (5), 433-45 PMID: 24224122

CDC - Breast Cancer Statistics

Exercise Cuts Breast Cancer Risk In Women

Walking May Cut Your Breast Cancer Risk

"Exercise Hormone May Prevent Breast Cancer" copyright © 2015 Living Fit, Healthy and Happy_(SM). All Rights Reserved.

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