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Obesity should not be taken lightly. It is a serious condition which can cause or be associated with a myriad of health problems including chronic pain, cardiovascular disease, liver disease, cancer, arthritis and diabetes. For the purposes of this article, I'm going to focus on obesity's adverse effect on overall health and fitness.
People who suffer from obesity are in a constant state of inflammation. This is caused by the continuous synthesis and release of inflammatory cytokines. Cytokines serve a very important role in the body such as cellular communication. But some of these molecules cause inflammation.
Pro-inflammatory cytokines are often associated with sensations of pain, which some researchers believe is the result of cytokine stimulation of pain receptors1.
Most fitness participants are familiar with delayed onset muscle soreness, but obese and overweight people have to contend with chronic pain that is caused by pro-inflammatory cytokines.
Thus, it's quite understandable that many of these folks shy away from exercise. The unfortunate downside is that people who don't take steps to increase their energy expenditure (and thereby burn fat energy) will continue to release inflammatory cytokines from their fat tissue thereby leading to a vicious cycle of chronic inflammation, pain and weight gain.
Cytokines also have a direct effect on cardiovascular health.
Proinflammatory cytokines play a role in development of heart disease, as these protein molecules are known to trigger the progression of atherosclerosis2.
Cardiovascular exercise is a useful means of staving off heart disease, but if a person is in too much pain to workout, how are they going to get into shape in the first place?
Now, I'm going to ask you something: wouldn't it be fantastic if chronic inflammation could be reduced naturally?
Bergomot Citrus Plant Naturally Reduces Inflammation
Interestingly, medical scientists have been hard at work seeking natural remedies for inflammation. Much research is being conducted on the anti-inflammatory properties of edible plants.
Researchers have discovered that a special type chemical derived from the bergamot citrus fruit can reduce inflammation. This compound is known as as bergamot polyphenolic fraction (BPF).
Taking a peek at a remarkable study published in PLoS ONE we can start to get a sense of what bergomot can do.
Italian scientists sought to understand bergamot's ability to reduce inflammation. Michele Navarra and colleagues from the University of Messina and the University of Salerno used human tissue cultures which were stimulated to release pro-inflammatory cytokines3. Then they treated the tissues with bergamot and discovered that the citrus plant was able to lower the release of pro-inflammatory cytokines3. Moreover, bergomot helped inhibit pro-inflammatory pathways3.
In a separate and unrelated study, University of Ferra scientists whom were investigating the use of medical plants for treatment of cystic fibrosis learned that bergomot was able to inhibit a cytokine involved in lung inflammation4.
A published article in American Journal of Physiology - Endocrinology and Metabolism discusses a correlation between saturated fatty acids and inflammation5. Additionally, researchers published a report in Lipids in Health and Disease discussing a relationship between high levels of cholesterol, pro-inflammatory cytokines and heart disease6.
There is also a relationship between obesity and non-alcoholic fatty liver disease (NAFDLD) (refer to our sponsored article Exciting Anti-Aging Research: Bergamot Stimulated AMPK Release May Keep Your Body Healthy). People who suffer from NAFLD have high amounts of serum cholesterol, low density lipoprotein (LDL) and low amounts of high density lipoprotein (HDL)7.
By now you should be coming to appreciate the fact that obese people are at great risk for heart disease. The aforementioned studies further support a relationship between heart disease and obesity and pro-inflammation.
Bergamonte May Help You Get Into Better By Helping Healthy Inflammation
We have learned that obesity can cause discomfort and increase health risks.
Now, I'm going to ask you another question: If there was a product on the market that could help improve cardiovascular health, you would rush out to buy it, wouldn't you?
Well, there just so happens that such a product exists. The product is called Bergamonte and it's distributed by Nutri Lifescience.
Scientific testing has demonstrated that Bergamonte can help replace bad cholesterol with good cholesterol and reduce liver inflammation (insert 6th reference here, too) which ultimately helps improve cardiovascular health. When the heart is healthier it may indeed help you to better participate in physical exercise and get into better shape.
Bergamonte vegetarian capsules which are distributed by Nutri Lifescience are made from bergamot citrus fruit extract and contain the bergamot polyphenolic fraction that I discussed throughout this article.
Bergamonte Discounts and a Free Giveway!
Right now Nutri Lifescience and Amazon are offering some great discounts on this health supplement product.
Get a15% discount off any purchase of Bergamonte! When you buy 3 bottles on Amazon you get the 3rd bottle free! Just click on the Amazon button!
That's not all!
Right now there's a Nutri Lifescience Bergamonte Giveway hosted on Amazon! Now through Monday September 20 go to Amazon and enter for your chance to win a bottle of Bergamonte capsules. Amazon will select the winner and send the prize directly to the winner. Go to https://giveaway.amazon.com/p/d3fd5c6da3a3a0d9 and enter now! No purchase necessary!
But even if you should suffer for what is right, you are blessed. "Do not fear what they fear ; do not be frightened." 1 Peter 3:14
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- Zhang, J., & An, J. (2007). Cytokines, Inflammation, and Pain International Anesthesiology Clinics, 45 (2), 27-37 DOI: 10.1097/AIA.0b013e318034194e
- Mehra,V.C., Ramgolam,V.S., & Bender, J.R. Cytokines and cardiovascular disease Journal of Leukocyte Biology, 78 (4) 805 - 818 doi: 10.1189/jlb.0405182
- Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, Ientile R, & Navarra M (2014). Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes. PloS one, 9 (9) PMID: 25260046
- Borgatti M, Mancini I, Bianchi N, Guerrini A, Lampronti I, Rossi D, Sacchetti G, & Gambari R (2011). Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC biochemistry, 12 PMID: 21496221
- Izadpanah A, Barnard RJ, Almeda AJ, Baldwin GC, Bridges SA, Shellman ER, Burant CF, & Roberts CK (2012). A short-term diet and exercise intervention ameliorates inflammation and markers of metabolic health in overweight/obese children. American journal of physiology. Endocrinology and metabolism, 303 (4) PMID: 22713506
- Persson J, Nilsson J, & Lindholm MW (2006). Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages. Lipids in health and disease, 5 PMID: 16800873
- Gliozzi, M., Maiuolo, J., Oppedisano, F., & Mollace, V. (2015). The effect of bergamot polyphenolic fraction in patients with non alcoholic liver steato-hepatitis and metabolic syndrome PharmaNutrition DOI: 10.1016/j.phanu.2015.11.003
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