by

Joseph

People diagnosed with Chronic Lymphocytic Leukemia (CLL) often receive a mixture of two powerful medications - the drug obinutuzumab combined with the chemotherapy drug chlorambucil. Although this approved therapy has helped many CLL patients, the drugs are not effective for all patients.

TG Therapeutics, recognizing the need for new drugs to treat CLL, has started a clinical to determine if two investigational drugs will be helpful to CLL patients. 

Therefore, researchers are studying the combination of two investigational drugs, Ublituximab and TGR-1202, to learn if they may be effective as a new treatment for CLL.

As a CureClick Ambassador I want to share this information with my readers because it could be helpful for medically treating people who have the troubling condition.

According to the research sponsor "This study is evaluating whether the new combination results in better outcomes for patients with CLL, including living longer without their CLL getting worse, compared to the approved therapy."

In summary, this is a phase 3 trial meaning that the study drug has been taken by other participants under the supervision of medical professionals.

The research trial will consist of 450 people who must meet certain criteria.

To learn more about eligibility requirements, please visit https://trialreach.com/prescreening/s/836/ .

For those of you whom are not familiar with clinical trials, here's some information that you can use:

by

Joseph

Approximately 29.1 million people in the US are affected by diabetes, and as a result are at risk of developing ulcers on their feet. Sadly, diabetics who suffer from foot ulcers often these open wounds or sores on the bottom of their feet. If the ulcer becomes infected, this could become very serious, and may require amputation. Better treatment for Diabetic Foot Ulcers is needed to prevent and treat this condition.

At this moment medical scientists are looking for new medications to treat diabetic foot ulcers.

Local doctors are enrolling research studies to develop potential medications for people with diabetes and foot ulcers. You may qualify for local research studies. But don’t delay – space is limited!

As a CureClick Ambassador I want to share this information with my readers because it could be helpful for medically treating people who have the troubling condition.

Conditions

Type 1 diabetes, type 2 diabetes, foot ulcer, diabetic peripheral neuropathy

For trial eligibility questionnaire and full trial details, please visit the sponsor website .

For those of you whom are not familiar with clinical trials, here's some information that you can use:

What Are Clinical Trials?

Clinical trials are research studies to determine whether investigational drugs or treatments are safe and effective for humans.

All investigational devices and medicines must undergo several clinical trials, often times these clinical trials require thousands of people.

Why participate in a clinical trial?

People whom are eligible will have access to new investigational treatments that would be available to the general public only upon approval.

People whom are eligible for clinical trials will also receive study-related medical care and attention from clinical staff at research facilities.

Clinical trials offer hope for many people and gives researchers a chance to find better treatment for others in the future.

Disclaimer: I am not participating in this clinical trial. I am providing this information to my readers as a CureClick Ambasssador. Click on the links below to learn about my relationship with Cureclick and why I'm talking about clinical trials.

by

Joseph

I have important news for migraine sufferers. Migraines interfere with quality of life. Acurian Health is recruiting people who suffer from frequent migraine headaches for participation in a study to develop better treatments. Right now local doctors are enrolling research studies to develop potential new medications.

Participants will receive no cost medications and help researchers learn better ways to treat migraine headaches.

As a CureClick Ambassador I want to share this information with my readers because it could be helpful for medically treating people who have the troubling condition.

For trial eligibility questionnaire and full trial details, please visit the sponsor website .

For those of you whom are not familiar with clinical trials, here's some information that you can use:

What Are Clinical Trials?

Clinical trials are research studies to determine whether investigational drugs or treatments are safe and effective for humans.

All investigational devices and medicines must undergo several clinical trials, often times these clinical trials require thousands of people.

Why participate in a clinical trial?

People whom are eligible will have access to new investigational treatments that would be available to the general public only upon approval.

People whom are eligible for clinical trials will also receive study-related medical care and attention from clinical staff at research facilities.

Clinical trials offer hope for many people and gives researchers a chance to find better treatment for others in the future.

Disclaimer: I am not participating in this clinical trial. I am providing this information to my readers as a CureClick Ambasssador. Click on the links below to learn about my relationship with Cureclick and why I'm talking about clinical trials.

http://curec.lk/2fALTBv

You make the lame walk straight, give sight to the blind and open the ears of the deaf, you give words to the mute and life to the dead. You are the Lord Jesus Christ. You are the only begotten Son of God.

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Bone Strengthening Drugs Linked to Lower Breast Cancer Incidence | Bone Strengthening Drugs

Submitted by: Medico News

New research from the US has discovered that women who used bisphosphonates, commonly-prescribed bone-strengthening drugs, had significantly fewer invasive breast cancers than women who did not use them. “The idea that bisphosphonates could reduce breast cancer incidence is very exciting because there are about 30 million prescriptions for these agents written annually in the US targeting bone health, and more could easily be used to counteract both osteoporosis and breast cancer,” Chlebowski told the media. For the study, Chlebowski and colleagues re-analyzed data from the Women’s Health Initiative (WHI), a large observational study set up by the National Institutes of Health (NIH) in 1991 to examine the most common causes of death, disability and impaired quality of life in postmenopausal women. The WHI collected information on cardiovascular disease, cancer, and osteoporosis.

In the 150,000-plus cohort of generally healthy postmenopausal women, the researchers found 32 per cent fewer cases of invasive breast cancer among women who used bisphosphonates (mostly alendronate, marketed as Fosamax by Merck), compared to women who did not use such drugs.

What prompted the study were the findings of a report from a breast cancer trial that suggested bisphosphonate zoledronic acid given intravenously every 6 months resulted in fewer cancers in the other breast.

Chlebowski said that:

“It appeared to make bone less hospitable to breast cancer.”

In deciding how to devise the study, the researchers had to find a way to control for bone density, since that in itself is a risk factor for breast cancer. In other words they had to devise a way to control for potential differences between the women prescribed bisphosphonate and those not prescribed bisphosphonate, because those on the bone-strengthening drugs were on it because they had low bone mineral density, which is linked to lower breast cancer incidence.

They found that about 10,000 of the cohort had their bone mineral density analyzed as part of the WHI study, and for the others, including those prescribed bisphosphonates, the researchers used a 10-item hip fracture predictive score to measure bone density.

Thus they were able to correlate the results of bone mineral density tests in the 10,000 who had the tests with the predictive score in order to correct for any potential difference in bone density in women using bisphosphonates compared to those who did not use them.

Thus prepared, Chlebowski and colleagues then studied data on 2,216 women who were using bisphosphonates when they entered the WHI study.

The results showed that:

Only 64 of the bisphosphonate users developed breast cancer, and most of the cases, (50 of them), were estrogen-receptor positive.

Overall there was an average of 32 per cent fewer breast cancers among bisphosphonate users compared to non-users.

There were 30 per cent fewer estrogen-receptor positive cancers and 34 per cent fewer entry-receptor negative cancers among bisphosphonate users, although the latter finding was not statistically significant due to low numbers.

Speculating on what effect bisphosphonates might have to cause fewer breast cancers, Chlebowski said it could be because the drugs discourage blood vessel formation (which tumors rely on to grow), and help the immune system:

“Bisphosphonates reduce angiogenesis and stimulate immune cells responsible for tumor cell surveillance as potential mediators,” explained Chlebowski.

He said we need to study this link in more detail, because “while we currently have several options for reducing receptor positive breast cancers, none are available for receptor negative cancers”.

Other studies presented at the symposium pointed to a similar link between bisphosphonate use and lower breast cancer risk, and a number of breast cancer trials evaluating oral and intravenous uses of the drug are about to report randomized clinical trial evidence on it.

About the Author: Written by Medical News | Cancer News : http://mediconews.com Dental News : http://mediconews.com

Source: www.isnare.com
Permanent Link: https://www.isnare.com/?aid=792402&ca=Cancer+Survival

by

Joseph

As a CureClick Ambassador I want to share this information with my readers: AchieveMint is running an online study about Type 2 Diabetes management.

This is an online research study to learn about Type 2 Diabetes. This is an innovative, online-only study and will provide finger prick test kits to measure A1c values for the research surveys. It does not include medication, and there are no live visits.

As a CureClick Ambassador I'm excited to tell you about this online study.

For trial eligibility questionnaire and full trial details, please visit AchieveMint http://curec.lk/2dK2vms

What Are Clinical Trials?

Clinical trials are research studies to determine whether investigational drugs or treatments are safe and effective for humans.

All investigational devices and medicines must undergo several clinical trials, often times these clinical trials require thousands of people.

Why participate in a clinical trial?

People whom are eligible will have access to new investigational treatments that would be available to the general public only upon approval.

People whom are eligible for clinical trials will also receive study-related medical care and attention from clinical staff at research facilities.

Clinical trials offer hope for many people and gives researchers a chance to find better treatment for others in the future.

Disclaimer: I am not participating in this clinical trial. I am providing this information to my readers as a CureClick Ambasssador. To learn more about my relationship with CureClick and why I'm talking about clinical trials, please click on this links.

curec.lk/1Gb4toG

May our work be pleasing to you, Oh Lord.

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by

Joseph

Sometimes the search for a good doctor can be quite nerve wracking even under the best of circumstances, but the emotional burden becomes even greater when searching for doctors who are participating in clinical trials.

Trial Reach and CureClick know this; so they developed a tool which makes the search for clinical research trials a bit easier.

Last July CureClick and Trial Reach asked if I would like to help out with this task; since I'm a CureClick Ambassador I was happy to help.

At this very moment you can use the Trial Reach Clinical Trials Search Tool that I embedded in the sidebar of Living Fit, Healthy and Happy_(SM).

The clinical trials search tool is absolutely amazing! The tool is designed so that users can search for any clinical trial for any condition. Then the tool provides relevant results based on the user answering a few questions. Now you can search for clinical trials that best fit your needs.

Although I receive a small one time payment for installing the Trial Reach Clinical Trials Search Tool on Living Fit, Healthy and Happy_(SM), the potential benefit to all of you is what inspired me to install it on this website. So, please take the time to use it. And tell all of your family and friends about it, too!

To learn more about my relationship with CureClick and why I'm talking about clinical trials, please click on this link.

curec.lk/1Gb4toG

God is the beginning and the end. God is God!

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"A Helpful Tool For People Searching For Clinical Research Trials" copyright © 2016 Living Fit, Healthy and Happy_(SM). All Rights Reserved.

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by

Joseph

Having high levels of good cholesterol doesn't necessarily prevent a person from developing heart disease, new research suggests. According to the results of a study published in Science, a rare genetic defect prevents cells from taking up circulating good cholesterol. This finding suggests that people with this genetic variant may require special attention to reduce their cardiovascular disease risk.

While most of us can rely on high density lipoprotein (HDL) to protect us from a build up of cholesterol in the bloodstream; this is due to the presence of Scavenger receptor BI (SR-BI) which binds cholesteryl esters to HDL in the liver. But an international team of researchers discovered that a rare gene prevents HDL from clearing cholesterol in certain individuals.

Research scientist Paolo Zanoni from the University of Pennsylvania, led a team which sought to better understand what would happen to cholesterol levels if the SR-BI was unable to properly do its job.

To find the answer, Zanoni et al used genetic sequencing to identify 328 individuals who carrying a rare defect that prevents SR-BI from functioning. People with the genetic defect are at great risk for cardiovascular disease.

To get a better handle on what this means, we need to take a step back and talk briefly about receptors and genes.

You can think of receptors as locks. When you want to enter a locked room, you need a key that fits the lock. If the lock is broken, you won't be able to open the door even though the key fits.

Genes can be thought of as the lock maker. If there is something wrong with the lock maker, it will produce defective locks.

Now imagine that you have a lot of deliveries arriving at a certain address, and a key is required to get into the room to deposit the deliveries. Because the lock doesn't work, the deliveries are left outside. Unfortunately, there's no way to stop the deliveries so they continue to arrive at the locked room. Eventually the deliveries pile up outside the room causing a huge problem.

That's what happens to people who have a broken SR-BI gene. Even though they have high levels of HDL (the good cholesterol), they're still at great risk for heart disease.

HDL can't properly bind the cholesteryl esters which which prevents the liver from removing excess cholesterol from the body the way it was meant to. Because the liver can't do its job, these people will have increased amounts of circulating cholesterol which eventually clogs the arteries thereby putting them at greater risk for heart attacks and strokes.

Therefore, identifying carriers of these defective genes and finding a way to correct the problem is very important.

How long, O LORD? Will you forget me forever? How long will you hide your face from me? How long must I take counsel in my soul and have sorrow in my heart all the day? How long shall my enemy be exalted over me? Psalm 13:1-2
Consider and answer me, O LORD my God; light up my eyes, lest I sleep the sleep of death, lest my enemy say, “I have prevailed over him,” lest my foes rejoice because I am shaken. Psalm 13:3-4
But I have trusted in your steadfast love; my heart shall rejoice in your salvation. I will sing to the LORD, because he has dealt bountifully with me. Psalm 13:5-6

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Article Reference

Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ, CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, & Global Lipids Genetics Consortium (2016). Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science (New York, N.Y.), 351 (6278), 1166-71 PMID: 26965621

"Rare Defect May Cause Good Cholesterol To Increase Heart Disease Risk" copyright © 2016 Living Fit, Healthy and Happy_(SM). All Rights Reserved.

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by

Joseph

Antibodies secreted from the mouth could be useful for predicting cancer risk, research suggests. According to the results of a study published in PloS one, scientists have found an inverse relationship between levels of salivary antibodies and cancer mortality in older adults. This finding could be useful in diagnosing cancer and developing potential treatments for disease.

A research team led by Anne C. Phillips from the School of Sport, Exercise & Rehabilitation Sciences, at the University of Birmingham in England selected 639 participants of the oldest cohort of the West of Scotland Twenty-07 Study; in 1995, the volunteers provided salivary immunoglobulin A (sIgA)  samples when they were 63 years of age. Researchers then measured saliva volume and sIgA concentration.

Scientists followed the participants for 19 years. They learned that participants with the highest concentration of sIgA had lower risk for all-cause mortality than volunteers who had very little salivary IgA.

In fact, the associations with all-cause mortality was found to be due to an underlying association with cancer deaths and particularly cancers other than lung cancer. Put another way, people who produced very small amounts of sIgA were at great risk for cancers that were not lung cancer.

On the other hand, people who produced high volumes of saliva immunoglobulin A were much more likely to not die from cancer (particularly non lung cancer) and respiratory diseases.

Immunoglobulin A is a special protein the body uses to protect itself from diseases such as the common cold and the flu; it is also very prolific in human saliva.

Phillips et al speculate that lower concentrations of sIgA makes people susceptible to disease, allowing cancers to emerge. That hypothesis could explain the higher association between cancer deaths and low sIgA observed in their study.

The research team recommended that future studies track cancer and respiratory disease deaths so that scientists can develop a better understanding of the associations in the current study.

In this regard they believe that "[a] comparison of sIgA and serum IgA in the context of specific mortality risk would also be informative in terms of the comparability of the prognostic value of these indicators."

"This is the first study to show this specific link between sIgA and mortality, and suggests that salivary IgA secretion rate could serve as an easily measurable marker of general mortality risk and particularly cancer-specific risk." Phillips et al concluded.

The work of Phillips et al is profound because it gives medical science another tool in the search for a cure for cancer.

Blessed are those whom are filled with the power of the LORD and go forth doing His work. Neither the devil nor the forces of this world can stop them and when all is said and done, their work brings glory to God.

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Article Reference

Phillips AC, Carroll D, Drayson MT, & Der G (2015). Salivary Immunoglobulin A Secretion Rate Is Negatively Associated with Cancer Mortality: The West of Scotland Twenty-07 Study. PloS one, 10 (12) PMID: 26699127

"Antibodies In Saliva Could Predict Cancer Mortality Risk" copyright © 2015 Living Fit, Healthy and Happy_(SM). All Rights Reserved.

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by

Joseph

A recent lab study may hold remarkable promise for the treatment and prevention of breast cancer.

According to the results of a study published in the International Journal of Cancer, researchers have demonstrated that a hormone released after exercise reduced migration and multiplication of malignant cancer cells.

If these results could be demonstrated in animal and human studies, medical science may have another weapon in the arsenal to treat and prevent breast cancer.

Kristina A Trujillo from the Department of Biochemistry and Molecular Biology at the University of New Mexico, and her colleagues from the University of New Mexico and Chapman University knew that exercise is beneficial for improving cancer prognosis  lowering disease risk, and that irisin provides benefits for metabolic diseases including cancer.

So the research scientists tested effects of various concentrations of the hormone on malignant and non-malignant breast cancer cells.

They found that irisin effectively reduced the migration, number and viability in malignant breast cancer cells while not harming non-malignant breast cancer cells.

Now this is an important finding, as I'm about to tell you.

Breast cancer is a very serious disease. In fact, the US Centers for Disease Control and Prevention (CDC) says that in 2011

• 22o,097 women and 2,078 men were diagnosed with the disease in the U.S.
• 40,931 women and 443 men in the US died from the disease

Breast cancer strikes any age or ethnicity. It is the second most common form of cancer among Asian/Pacific Islander, black, Alaskan/Native American, white and Hispanic women.

Cancer is dangerous and often deadly because it's mitosis run amok. Humans and animals replenish themselves through mitosis, a mechanism whereby cells multiply to make new versions of themselves.

It's a sophisticated and remarkable mechanism and often works very well. But God did allow for the human body and animal body to make mistakes thus sometimes cells go on multiplying even beyond the body's ability to sustain them.

The malignant cells can even spread to other parts of the body causing problems for other organ systems. If left to itself this will continue until the person or animal dies.

But irisin stops the malignant cells from multiplying, spreading to other cells and even more remarkable, fouls up the cancerous cells so that they will die.

Trujillo and her colleagues also noted that irisin enhanced effectiveness of doxorubicin (Dox) a cancer fighting medicine when added to vast spectrum of irisin concentrations in malignant cell types.

The research team also noted that irisin suppresses activation of NFκB; NFκB is a protein that regulates genes involved in inflammation and immune response. Thus NFκB helps cancerous cells to survive and proliferate.

Therefore it is very significant that irisin suppresses this ability.

I see this as further proof that God lives. He created mechanisms which can save as well as kill the body. It's up to us to figure out how these mechanisms work.

Exercise Can Save Lives

Other studies have shown that exercise can prevent breast cancer.

In a study involving 2609 female participants, scientists from Gillings School of Global Public Health at the University of North Carolina at Chapel Hill found that women who participated in moderate levels of exercise e.g. walking were able to reduce their chances of developing breast cancer by 30%.

Moreover, results of American Cancer Society Cancer Prevention Study II Nutrition Cohort study of 73,631 postmenopausal women found that post menopausal women who walked for even 1 hour per day lowered their breast cancer risk by 14% compared to women who didn't exercise.

While those studies involved humans, Trujillo et al tests on malignant and nonmalignant cells holds promise for the development of treatment methods in the future.

"Our observations suggest that irisin may offer therapeutic benefits for breast cancer prevention and treatment possibly through an anti-inflammatory response, induction of apoptotic cell death, or through enhanced tumor sensitivity to common antineoplastic agents such as Dox." Trujillo and her colleagues concluded.

1 But God remembered Noah and all the wild animals and the livestock that were with him in the ark, and he sent a wind over the earth, and the waters receded. Genesis 8:1

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Article Reference

Gannon NP, Vaughan RA, Garcia-Smith R, Bisoffi M, & Trujillo KA (2015). Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behavior in vitro. International journal of cancer. Journal international du cancer, 136 (4) PMID: 25124080

Chang TP, & Vancurova I (2013). NFκB function and regulation in cutaneous T-cell lymphoma. American journal of cancer research, 3 (5), 433-45 PMID: 24224122

CDC - Breast Cancer Statistics

Exercise Cuts Breast Cancer Risk In Women

Walking May Cut Your Breast Cancer Risk

"Exercise Hormone May Prevent Breast Cancer" copyright © 2015 Living Fit, Healthy and Happy_(SM). All Rights Reserved.

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by

Joseph

I have some news which could be of value to people with type 2 diabetes. Merck Sharp & Dohme Corp. is recruiting people with type 2 diabetes for a clinical trial.

The trial involves the evaluation of an investigational medicine for people with type 2 diabetes who aren't currently on any diabetes medication.

As a CureClick Ambassador I want to share this information with my readers because it could be helpful in the treatment of the disease.

Information about the clinical trial and eligibility requirements are listed below:

Title

Type 2 Diabetes

Condition

type 2 diabetes

Phase

Phase 3

Description

This research study is evaluating a new investigational medicine for people with type 2 diabetes, who are not currently on any diabetes medication. The study medicine is being evaluated to see if it can improve the management of type 2 diabetes by reducing blood sugar levels.

Enrollment

200

Sponsor

Merck Sharp & Dohme Corp.

Drug

MK-3102

Age Range

18 - 44 years old

Stage

recruiting

For trial eligibility questionnaire and full trial details, please visit our partner TrialReach.

For those of you whom are not familiar with clinical trials, here's some information that you can use:

What Are Clinical Trials?

Clinical trials are research studies to determine whether investigational drugs or treatments are safe and effective for humans.

All investigational devices and medicines must undergo several clinical trials, often times these clinical trials require thousands of people.

Why participate in a clinical trial?

People whom are eligible will have access to new investigational treatments that would be available to the general public only upon approval. 

People whom are eligible for clinical trials will also receive study-related medical care and attention from clinical staff at research facilities.

Clinical trials offer hope for many people and gives researchers a chance to find better treatment for others in the future.

Disclaimer: I am not participating in this clinical trial. I am providing this information to my readers as a CureClick Ambasssador. Click on My Relationship To CureClick to learn why I'm talking about clinical trials.

http://curec.lk/1MdAcsd

curec.lk/1Gb4toG

8 Produce fruit in keeping with repentance. And do not begin to say to yourselves, 'We have Abraham as our father.' For I tell you that out of these stones God can raise up children for Abraham. Luke 3:8

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